Endocrine Abstracts

Over one hundred years ago Ramon y Cajal proposed that developing axonsmight be guided to their targets by diffusible chemical signals but thefirst evidence that this was possible did not emerge until 1983. Ten yearslater saw the first evidence for diffusible repellent signals that restrictthe territories occupied by axons and the first identified chemorepellent,c...

Many conditions may interfere with intestinal absorption of levothyroxine (L-T4). In addition, it has been demonstrated a failure in the normalisation of TSH values in patients consuming L-T4 tablets with coffee or with water followed by coffee taken shortly afterwards. Recent studies showed that oral liquid L-T4 could remove the problem of L-T4 malabsorption by coffee and f...

Introduction: Obesity is characterized by an expanded and chronically inflamed adipose tissue (AT). The galectin (Gal) family of proteins exerts a variety of activities, including regulation of inflammation and adipogenesis.Methods: We used RT-PCR, ELISA and flow cytometry to evaluate regulation of expression and production of 4 members of the Gal family – Gal1, Gal3, Gal9 and Gal12 – in visceral (VAT) and subcutaneous (SAT) adipose tissue of m...

Background: Extreme hypercalcemia is an endocrine emergency. Given parathyroid hormone (PTH)-dependent cause, carcinoma should be suspected as a possible etiology. The prevalence of parathyroid carcinoma among patients presenting with extreme hypercalcemia is not well elucidated.Aim: Establish proportion of patients with parathyroid carcinoma among those presenting with severe hypercalcemia and compare clinical and laboratory features between benign and ...